EDK
Editome Disease Knowledgebase
Breast Cancer
| Disease name | Breast Cancer |
|---|---|
| Classfication | Cancer |
| Related Enzyme(s) | |
| EFO | EFO:0000305 |
| DOID | 1612 |
| OMIM | |
| NCI | |
| Definition | Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| DHFR | Human | ADAR1 | 25 | G-to-A | ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3 -UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. | |||
| DFFA | Human | ADAR1 | 1 | A-to-I | mRNA editing allowed this miRNA to directly target the apoptosis inducing gene DFFA in MCF-7, but not in MDA-MB-231 cells. | |||
| ATM | Human | ADAR1 | 21 | A-to-I | Editing was particularly increased in the 3′UTRs of ATM, GINS4 and POLH transcripts in tumors, which correlated with their mRNA expression. | |||
| GNL3L | Human | ADAR1 | 1 | A-to-I | RNA editing could contribute towards aberrant synaptic formation in ASD | |||
| POLR2F | Human | ADAR1 | 1 | A-to-I | RNA editing could contribute towards aberrant synaptic formation in ASD |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-miR-200b | ADAR1;ADAR2 | 1 | A-to-I | MI0000342 | miR-200b editing shows correlations with TP53 in breast cancers. High editing level in miR-200b is associated with worse patient survival. | ||
| hsa-miR-99a | ADAR1;ADAR3 | 1 | A-to-I | MI0000101 | miR-99a editing shows correlations with TP53, HRAS, MAP3K1, PIK3CA in breast cancer, head and neck cancer, thyroid cancer. |
| Enzyme | Full Name | Location | Ensembl | Targets | Related Diseases | Aliases |
|---|---|---|---|---|---|---|
| ADAR1 | Adenosine deaminase, RNA specific | Chr1:154582057..154631560 |
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